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CAN YOU HELP DIEDERIK?
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TPI-Helpathon #5a
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From
10/13/2021
until
10/14/2021
13h00-13h00
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20
Volunteer wanted
Objective: developing a non-animal model for metabolic stress for obesity of the heart/muscle cell function.
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Diederik Kuster is a scientist in Physiology at the Amsterdam UMC/VUmc and working on hypertrophic cardiomyopathy. 


Hypertrophic cardiomyopathy is one of the most common inherited heart diseases. It is caused by a mutation in the contraction proteins of the heart. But while some patients develop complications early on, others do so much later - or even never. So a second hit is needed for the disease to develop. How does that second hit work? We know that metabolic stress and therefore diet (for example obesity) is a factor. But there is a lot that we still don’t know about this second hit. Modeling it is complex and perhaps not yet possible without the use of animal models. Or is it?

"Since 1989 we have had no big breakthrough in our knowledge of this common disease. We know a lot about causes and consequences, but if we found out more about what happens in between we would know much better who to help and how. It's a puzzle worth solving."

Diederik wants to develop a non-animal model for metabolic stress, linked to obesity, which in turn has an effect on the heart/muscle cell function. Can you help him to solve his puzzle? 


Register below to help science and Diederik move forward! 

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